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Avoid getting overheated or dehydrated

Patients should be advised that they may experience weight gain. The primary rating instrument used for assessing manic symptoms in these trials was the Young Mania Rating Scale YMRS an 11-item clinician-rated scale traditionally used to assess the degree of manic symptoms in a range from 0 no manic features to 60 maximum score. San Diego company that conducts medication studies for drug companies. SEROQUEL may enhance the effects of certain antihypertensive agents. naproxen price news

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Fleischhacker WW, Hummer M. Drug treatment of schizophrenia in the 1990s: achievements and future possibilities in optimising outcomes. Drugs. The higher dose showed no added benefits, so the 300 milligram daily dose is what's recommended, says AstraZeneca. If you are taking extended-release capsules, swallow them whole. not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

What are the possible side effects of seroquel

This product is safe to take during when used as directed. Certain spinal cord may be prevented by maintaining adequate amounts of during pregnancy. Consult your doctor or pharmacist for details. This study included patients with bipolar I and II disorder, and those with and without a rapid cycling course. Patients randomized to Seroquel XR were administered 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4 and after. Our Seroquel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This does not usually have bothersomeside effects when used as directed.

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Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. When treating pediatric patients with SEROQUEL for any indication, weight gain should be assessed against that expected for normal growth. Available as quetiapine fumarate; dosage is expressed in terms of quetiapine. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Food and Drug Administration. Public health advisory: deaths with antipsychotics in elderly patients with behavioral disturbances. Rockville, MD; 2005 Apr 11. From the FDA website.



Widely distributed throughout the body

Keep all away from children and pets. SEROQUEL or breast-feed. You should not do both. Appropriate studies have not been performed on the relationship of age to the effects of quetiapine extended-release tablets and tablets in children with schizophrenia younger than 13 years, in children with bipolar mania younger than 10 years, and in children with bipolar depression younger than 18 years. Safety and efficacy have not been established in these age groups. There are no systematically collected data to specifically address switching patients from other antipsychotics to Seroquel XR, or concerning concomitant administration with other antipsychotics. While immediate discontinuation of the previous antipsychotic treatment may be acceptable for some patients, more gradual discontinuation may be most appropriate for others. In all cases, the period of overlapping antipsychotic administration should be minimized. When switching patients from depot antipsychotics, if medically appropriate, initiate Seroquel XR therapy in place of the next scheduled injection. The need for continuing existing extrapyramidal syndrome medication should be re-evaluated periodically. Anon. Academic highlights: Seroquel: a putative atypical antipsychotic drug with serotonin- and dopamine-receptor antagonist properties: preclinical and early clinical trials in schizophrenia. J Clin Psychiatry. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. There is no specific antidote to Seroquel XR. Therefore, appropriate supportive measures should be instituted. The possibility of multiple drug involvement should be considered. Please refer to the for information on shortages of one or more of these preparations. If your symptoms do not improve or if they become worse, check with your doctor. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; confusion; difficult or painful urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; increased saliva production or drooling; increased sweating; memory problems; menstrual changes; muscle pain, stiffness, or weakness; new or worsening mental or mood changes eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness; numbness, burning, or tingling; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or prolonged dizziness, light-headedness, or headache; severe stomach or back pain with or without nausea or vomiting; shortness of breath; suicidal thoughts or actions; swelling of the arms, hands, legs, or feet; symptoms of high blood sugar eg, increased thirst, hunger, or urination; unusual weakness; symptoms of high prolactin levels eg, decreased sexual ability, enlarged breast size, missed menstrual period, nipple discharge; tremor; trouble concentrating, speaking, or swallowing; trouble sleeping; trouble walking or standing; uncontrollable or involuntary muscle movements eg, loss of balance, twitching of the face or tongue, uncontrollable arm or leg movements; unusual bruising or bleeding; vision changes eg, blurred vision, decreased vision. Seroquel was already approved to treat the manic phases of formerly called manic-depressive illness.



Side effects of seroquel

If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Seroquel XR in the bipolar depression trial. This medication can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking quetiapine. Acute withdrawal symptoms, such as insomnia, nausea and vomiting have been described after abrupt cessation of atypical antipsychotic drugs, including quetiapine fumarate. The mechanism of action of Seroquel XR in the treatment of schizophrenia, bipolar disorder and major depressive disorder MDD is unknown. However, its efficacy in schizophrenia could be mediated through a combination of dopamine type 2 D 2 and serotonin type 2A 5HT 2A antagonism. The active metabolite, N-desalkyl quetiapine norquetiapine has similar activity at D 2, but greater activity at 5HT 2A receptors, than the parent drug quetiapine. Taking this medication after your evening meal or at may help if you have upset or with the medication. You may choose to take this medication at another time of day that is easier for you to remember. No matter what dosing schedule you use, it is very important that you take this medication at the same time each day, 24 hours apart. Psych-Higher risk of tardive dyskinesia. Anticholinergic effects cause sedation, worsen cognitive impairment and increase fall risk. Increased risk of death in senile dementia. Cardiovascular-May cause orthostatic hypotension at higher doses. Higher incidence of stroke and transient ischemic attacks. If you feel you need to stop Seroquel XR, talk with your healthcare provider first. If you suddenly stop taking Seroquel XR, you may have side effects such as trouble sleeping or trouble staying asleep insomnia nausea, and vomiting. Following multiple dosing of quetiapine up to a total daily dose of 800 mg, administered in divided doses, the plasma concentration of quetiapine and norquetiapine, the major active metabolite of quetiapine, were proportional to the total daily dose. Accumulation is predictable upon multiple dosing. Steady-state mean C max and AUC of norquetiapine are about 21-27% and 46-56%, respectively of that observed for quetiapine. Elimination of quetiapine is mainly via hepatic metabolism. The mean-terminal half-life is approximately 7 hours for quetiapine and approximately 12 hours for norquetiapine within the clinical dose range. Steady-state concentrations are expected to be achieved within two days of dosing. Seroquel XR is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P450 enzymes. trihexyphenidyl



How should i take seroquel

If you are taking chewable tablets, chew the tablet thoroughly before swallowing. Use with caution. May make these conditions worse. Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents. In therapy for schizophrenia up to 6 weeks the most commonly observed adverse reactions associated with the use of quetiapine in adolescents incidence of 5% or greater and quetiapine incidence at least twice that for placebo were somnolence 34% dizziness 12% dry mouth 7% tachycardia 7%. Sussman N. The implications of weight changes with antipsychotic treatment. J Clin Psychopharmacol. Do not suddenly stop taking this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This will decrease the chance of having withdrawal symptoms such as nausea, vomiting, insomnia, dizziness, irritability, or headache. If signs and symptoms of tardive dyskinesia appear in a patient on Seroquel XR, drug discontinuation should be considered. However, some patients may require treatment with quetiapine despite the presence of the syndrome. This section provides information on the proper use of a number of products that contain quetiapine. It may not be specific to Seroquel. Please read with care. Tell the healthcare provider about all the medicines that you take or recently have taken including prescription medicines, over-the-counter medicines, herbal supplements and vitamins. The study was presented at the 9th International Conference on Alzheimer's Disease and Related Disorders. Prescribe in smallest quantity consistent with good patient management to reduce risk of overdosage. No suicides occurred in any of the pediatric trials. There were suicides in the adult trials, but the number was not sufficient to reach any conclusion about drug effect on suicide. Table 14: Adverse Reactions in an 8-Week Placebo-Controlled Clinical Trial for the Treatment of Bipolar Depression Somnolence combines adverse reaction terms somnolence and sedation. Extrapyramidal symptoms include the terms: muscle spasms, akathisia, dystonia, extrapyramidal disorder, hypertonia, and tremor. If the medication gets in these areas, rinse immediately with clean water. generic toprol does it actually work toprol



Seroquel dosage

Since quetiapine has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about performing activities requiring mental alertness, such as operating a motor vehicle including automobiles or operating hazardous machinery until they are reasonably certain that quetiapine therapy does not affect them adversely. Somnolence may lead to falls. The primary rating instrument used to assess depressive symptoms in these studies was the MADRS. The primary endpoint in both studies was the change from baseline in MADRS score at week 8. In both studies, SEROQUEL was superior to placebo in reduction of MADRS score at week 8 Studies 7 and 8 in Table 29. In these studies, no additional benefit was seen with the 600 mg dose. For the 300 mg dose group, statistically significant improvements over placebo were seen in overall quality of life and satisfaction related to various areas of functioning, as measured using the Q-LES-QSF. In both studies, SEROQUEL was superior to placebo in increasing the time to recurrence of any mood event Figure 2 and Figure 3. The treatment effect was present for increasing time to recurrence of both manic and depressed episodes. The effect of SEROQUEL was independent of any specific subgroup assigned mood stabilizer, sex, age, race, most recent bipolar episode, or rapid cycling course. Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs SSRIs and others showed that these drugs increase the risk of suicidal thinking and behavior suicidality in children, adolescents, and young adults ages 18-24 with major depressive disorder MDD and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older. It works by temporarily narrowing the vessels in the area. This effect decreases swelling and discomfort. Eli Lilly and Company. Lilly announces FDA notification of class labeling for atypical antipsychotics regarding hyperglycemia and diabetes. Indianapolis, IN; 2003 Sep 17. Press release. Eli Lilly and Company. Zyprexa olanzapine tablets and Zyprexa Zydis olanzapine orally disintegrating tablets prescribing information. TSH increases in monotherapy studies. Keep Seroquel XR and all medicines out of the reach of children. Elevated prolactin concentrations reported with some atypical antipsychotic agents; not observed in clinical trials with quetiapine but reported in animals. However, there was evidence of embryo-fetal toxicity. buy cefixime payment canada



What conditions does seroquel treat

When indicated, dose escalation should be performed with caution in these patients. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. Torrey EF, Swalwell CI. Fatal olanzapine-induced ketoacidosis. Am J Psychiatry. Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide. Check your pressure regularly and tell your doctor if the results are high. It is 83% bound to plasma proteins at therapeutic concentrations. In vitro, quetiapine did not affect the binding of warfarin or diazepam to human serum albumin. In turn, neither warfarin nor diazepam altered the binding of quetiapine. Panic Attacks, and again tried another SSRI that was fairly new to me at the time called Celexa. I took it for about a month or so until the same side effects I have always had with SSRIs began. So I went to my new doctor and explained this to him. He then prescribed me Seroquel to try as an alternative to an SSRI, at first at a low dosage, than higher as I needed it. Not only did it NOT cause the same unwanted side effects as the SSRIs did, it eased my conditions very well and proved to be extremely effective. It has successfully countered my Bi-Polar Disorder for the last 3 or so years. Follow all directions on the product package. illo.info cefadroxil



Includes SEROQUEL and Seroquel XR data

Thyroid follicular cell adenomas may have resulted from chronic stimulation of the thyroid gland by thyroid stimulating hormone TSH resulting from enhanced metabolism and clearance of thyroxine by rodent liver. Changes in TSH, thyroxine, and thyroxine clearance consistent with this mechanism were observed in subchronic toxicity studies in rat and mouse and in a 1-year toxicity study in rat; however, the results of these studies were not definitive. The relevance of the increases in thyroid follicular cell adenomas to human risk, through whatever mechanism, is unknown. Mild or flushing may occur. These effects are usually temporary and may disappear as your body adjusts to this product. If any of these effects persist or worsen, contact your doctor or promptly. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor. In 2 of the 8 hepatically impaired patients, AUC and C max were 3 times higher than those observed typically in healthy subjects. Seroquel XR is a trademark of the AstraZeneca group of companies. This finding may be due to inhibition of cholesterol biosynthesis by quetiapine. Quetiapine caused a dose-related reduction in plasma cholesterol levels in repeat-dose dog and monkey studies; however, there was no correlation between plasma cholesterol and the presence of cataracts in individual dogs. The appearance of delta 8 cholestanol in plasma is consistent with inhibition of a late stage in cholesterol biosynthesis in these species. There also was a 25% reduction in cholesterol content of the outer cortex of the lens observed in a special study in quetiapine treated female dogs. What should I avoid while taking quetiapine Seroquel? Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Table 30: Major Depressive Disorder, Adjunctive Therapy to Antidepressants Difference drug minus placebo in least-squares mean change from baseline. Doses that are statistically significantly superior to placebo.



Seroquel forms and strengths

QT prolongation, the elderly, congestive heart failure and heart hypertrophy. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. At first, 50 mg once a day in the evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 800 mg per day. SEROQUEL may affect your test results. The drug is not approved for use in children. Check the labeling for Seroquel's warnings. store eskazole buy



TSH increases in monotherapy studies

Some drugs may cause hormonal to work less well by decreasing the amount of hormones in your body. Patients and caregivers should be advised that elderly patients with dementia-related psychoses treated with atypical antipsychotic drugs are at increased risk of death compared with placebo. This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or urination. If you have diabetes, the results of your urine or blood sugar tests may change. Check your blood sugar closely and talk with your doctor if you have any questions. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests eg, urine drug screens may be affected by this medicine. SEROQUEL was at least twice the incidence in placebo-treated patients. Food and Drug Administration. FDA news: FDA proposes new warnings about suicidal thinking, behavior in young adults who take antidepressant medications. Rockville, MD; 2007 May 2. From the FDA web site. Bushe C, Leonard B. Association between atypical antipsychotic agents and type 2 diabetes: review of prospective clinical data. Br J Psychiatry Suppl. Positive and Negative Syndrome Scale PANSS. Seroquel XR sustained-release tablets may increase the amount of a certain hormone prolactin in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms. Citrome L, Volavka J. Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statement. Diabetes Care. In hot weather, stay inside in a cool place if possible. buy tecta use



List of seroquel side effects

Importance of avoiding overheating or dehydration. Wehring HJ, Kelly DL, Love RC et al. Deaths from diabetic ketoacidosis after long-term clozapine treatment. Am J Psychiatry. Appropriate studies have not been performed on the relationship of age to the effects of quetiapine extended-release tablets to treat major depressive disorder in the pediatric population. Safety and efficacy have not been established. MDD and other psychiatric disorders. EPS. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology. You will need to have your blood pressure measured before starting this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away. If you have questions about this, talk to your doctor. This medication should not be used during pregnancy. If you become or think you may be pregnant, tell your doctor right away. Importance of providing written patient information medication guide each time quetiapine is dispensed. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. Melkersson K, Dahl ML. Adverse metabolic effects associated with atypical antipsychotics. Drugs. The efficacy of Seroquel XR in the treatment of schizophrenia in adolescents 13-17 years of age was supported by a 6-week, double-blind, placebo-controlled trial. acyclovir



How to take seroquel

Gastrointestinal-May cause or worsen pre-existing constipation. Urogenital-Best avoided in patients with urinary retention. Elavil, Vanatrip, Limbitrol clozapine FazaClo, Clozaril fluoxetine Prozac, Sarafem, Symbyax haloperidol Haldol risperidone Risperdal thioridazine Mellaril and others. Seroquel showed promise at and generalized anxiety disorder. Those studies were also funded by AstraZeneca. What are the ingredients in SEROQUEL? Take SEROQUEL by mouth, with or without food. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Some MEDICINES MAY INTERACT with Seroquel. Pigment deposition was shown to be irreversible in rats. The outcome was a full night's sleep! This medicine is available only with your doctor's prescription. In vitro enzyme inhibition data suggest that quetiapine and 9 of its metabolites would have little inhibitory effect on in vivo metabolism mediated by cytochromes CYP 1A2, 2C9, 2C19, 2D6 and 3A4. Quetiapine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down. Inactive ingredients for Seroquel XR are lactose monohydrate, microcrystalline cellulose, sodium citrate, hypromellose, and magnesium stearate. The film coating for all Seroquel XR tablets contain hypromellose, polyethylene glycol 400 and titanium dioxide. In addition, yellow iron oxide 50, 200 and 300 mg tablets and red iron oxide 50 mg tablets are included in the film coating of specific strengths. bonviva



Highlights for seroquel

Seroquel should be used with extreme caution in CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed. At first, 50 milligrams mg 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 800 mg per day. Bess AL, Cunningham SR. Dear health care professional letter regarding class labeling for atypical antipsychotics and risk of hyperglycemia and diabetes. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2004 Apr 1. From the FDA website. Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms. SD: standard deviation; SE: standard error; LS Mean: least-squares mean; CI: unadjusted confidence interval. See Boxed Warning and also see Pediatric Use under Cautions. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Periodically reevaluate need for continuing any existing drug therapy for symptomatic relief of adverse extrapyramidal effects. There are no clinically relevant pharmacokinetic interactions of Seroquel on other drugs based on the CYP pathway. Seroquel and its metabolites are non-inhibitors of major metabolizing CYPs 1A2, 2C9, 2C19, 2D6 and 3A4.



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Seroquel warnings


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The information below is derived from a clinical trial database for Seroquel XR consisting of approximately 3400 patients exposed to Seroquel XR for the treatment of Schizophrenia, Bipolar Disorder, and Major Depressive Disorder in placebo-controlled trials. This experience corresponds to approximately 1020. Seroquel XR sustained-release tablets may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems, such as impotence. Contact your doctor right away if this happens. Quetiapine is used to treat schizophrenia in adults and children who are at least 13 years old.

What should i avoid while taking seroquel

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Robinson CP, Robinson KA, Castaner J. Quetiapine fumarate. Drugs Future. Tariot's study looked at whether these drugs worked to calm agitation in elderly patients with dementia living in a nursing home. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Seroquel uses

Take this medicine exactly as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Take Seroquel by mouth with or without food. FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. SEROQUEL, drug discontinuation should be considered. Screening Patients for Bipolar Disorder: A major depressive episode may be the initial presentation of bipolar disorder.

III trials Schizophr Res

Casey DE. Will the new antipsychotics bring hope of reducing the risk of developing extrapyramidal syndromes and tardive dyskinesia? Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member take. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider. Monitor behavior, weight, blood pressure, glucose, lipids. Possible increased risk of suicidal ideation and attempt. Higher incidence of nausea and vomiting. Risk of somnolence, tachycardia, irritability.

At first, 50 milligrams mg once a day in the evening. Your doctor may adjust your dose as needed. However, the dose is usually not more than 300 mg per day. It is best to begin taking this medication on the first day of your menstrual period. Quetiapine is used to treat bipolar disorder manic depression in adults and children who are at least 10 years old. Seroquel XR may antagonize the effects of levodopa and dopamine agonists. online daflon usa

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